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. 2022 Nov 9;613(7944):558–564. doi: 10.1038/s41586-022-05514-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a, Individual inhibition curves of recombinant live SARS-CoV-2 carrying single (left) and combination 3CL^pro mutations (right) by nirmatrelvir. Representative curves from a single experiment from three biologically independent experiments are shown. Error bars denote mean ± s.e.m of three technical replicates. b, Inhibition of recombinant live SARS-CoV-2 carrying single and combination 3CL^pro mutations by nirmatrelvir, ensitrelvir and remdesivir. Values shown are fold change of mean values in IC₅₀ relative to inhibition of WT from three biologically independent experiments.