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. 2023 Jan 18;13:976. doi: 10.1038/s41598-023-27537-z

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Proteomic analyses of D. immitis infected NSG mouse tissues. Principal component analyses (PCA) of plasma (a) and urine (c) illustrate changes in the proteome over time that are consistent within and between batches of mice and larva. Heat maps of the 28 proteins significantly altered in plasma (b) and 57 proteins significantly altered in urine (d) recapitulate the PCA analyses, displaying distinct proteomes at progressive timepoints in the infection. A general feature appears to be a downward trend in protein expression across plasma and urine as infection progresses.