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. 2023 Jan 18;13:976. doi: 10.1038/s41598-023-27537-z

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of ivermectin and moxidectin on susceptible and resistant isolates of D. immitis in NSG mice. NSG mice were infected for 6 weeks with either the ML-susceptible MO 2005 isolate or the ML-resistant JYD-34 isolate and treated on Day 0, 15 and 30 with (a) 0.01 mg/kg of Ivermectin or (b) moxidectin. *Statistically significant difference, p value ≤ 0.05 between placebo and treated groups. **Statistically significant difference, p value ≤ 0.05 between treated susceptible and resistant isolates.