Table 1.
Proteomic analyses of D. immitis infected NSG mouse tissues.
| Class | Molecules | Location | Action |
|---|---|---|---|
| Complement system | C1qc, C1ra, C2, C8/b/, C9 | Urine and plasma | ↓ |
| C4b | Urine | ↑ | |
| Pore forming | VDac1/2/3 | Urine and plasma | ↓ |
| Extracellular proteins | Plasminogen and Alpha-2-antiplasmin | Urine | ↓ |
| Collagen | Plasma | ↓ | |
| Annexin | Urine | ↑ | |
| Cfd, Mbl2 and Fibrinogen ƴ chain | Plasma | ↑ | |
| Cell adhesion (epithelia) | Cadherin-5 | Urine | Varied |
| Cadherin-16 | Plasma | Varied | |
| Desmogleins and desmoplakin | Urine | ↑ | |
| Decorin and laminin | Urine | ↓ | |
| Vacuolar and lysosomal activity | Chitobiase, neuraminidase, trehalase, mannosidase | Urine | ↓ |
| Multiple major urinary proteins | MUP members 1, 2, 3, 17 and 20) | Urine and plasma | ↓ |
| Renal markers | Ckb, Ckm, Ckmt1, Ckmt2, Ddah1, SDMA | Urine | Varied |
Summary of proteins significantly altered in NSG mouse plasma and urine.