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. 2023 Jan 18;14:301. doi: 10.1038/s41467-022-35716-1

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a–e Cartesian (X-Y) maps for the islets in Fig. 5a showing cell position in the islet and changes in internalization strength over time following application of vehicle (a), or exendin9 (b), or stimulation with exendin4 (c), semaglutide (d) or tirzepatide (e) (representative plots from n = 4 islets, 3 animals). f–j Cartesian (X-Y) maps showing cell subpopulations recruited into internalization at 10 min (subpopulation 1), 20 min (subpopulation 2) and 30 min (subpopulation 3) post-stimulation with vehicle (f), exendin9 (g), exendin4 (h), semaglutide (i) or tirzepatide (j), for the islets shown in Fig. 5a and the graphs displayed in Fig. 5b–e. k–o Number of cells recruited into internalization at each time point following stimulation with vehicle (k), exendin9 (l), exendin4 (m), semaglutide (n) or tirzepatide (o) (one-way RM ANOVA with Dunnett’s or Bonferroni’s post-hoc test; vehicle: F = 2.97, DF = 3; exendin9: F = 6.39, DF = 3; exendin4: F = 16.60, DF = 3; semaglutide: F = 6.99, DF = 3; tirzepatide: F = 3.16, DF = 3) (n = 4 islets, 3 animals). p Schematic showing relative effects of the various agonists on trafficking within cell sub-populations 1, 2, and 3 (font size = strength of effect). **P < 0.05, **P < 0.01, NS, non-significant. Violin plots show median and interquartile range. Source data are provided as a Source Data file.