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. 2023 Jan 5;13:1039588. doi: 10.3389/fphys.2022.1039588

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Copyright © 2023 AlSabagh, Rao and Renno.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Blood glucose levels of rats in different groups in short-term (A) and long-term (B) experiments. Note that there were no significant differences in blood glucose levels between groups before STZ injection (0 h) in both short and long-term experiments. However, the diabetic and diabetic + heat therapy group of rats (D3W, DH3W, D6W, and DH6W) showed a significant increase in blood glucose compared to respective control groups at all-time points of measurements (48 h, 3 and 6 weeks) after STZ injection (****, p < 0.0001, One-way ANOVA, Bonferroni multiple comparison tests, n = 6 in all groups) and there was no difference in blood glucose level between short- and long-term experiments.