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. 2023 Jan 18;6:68. doi: 10.1038/s42003-022-04350-4

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — A total of six different cancer types, including breast cancer (BCa; MDA-MB-231), prostate cancer (PCa; DU145, LNCaP, PC-3), ovarian cancer (OVA; CAOV3), pancreatic cancer (PANC; MIA PaCa-2, PANC1), melanoma (MELA; A375), and colorectal cancer (CRC; HT29, SW620), were investigated for their response to hypoxia. Heatmap representing the hypoxic log₂ fold change in comparison to sEVs derived from normoxic conditions. Cell lines did not consistently elevate the levels of all 6 proteins, or in some cases the expression of proteins was reduced, particularly evident in OVA and PANC. Grey denotes not detected.