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. 2023 Jan 18;14:298. doi: 10.1038/s41467-023-35937-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Workflow to identify differentially expressed genes, cis-regulatory elements (CRE) and transcription factors (TFs) associated with wnt1 (RNAi). Next to each workflow the program used is indicated. Motif discovery for TCF binding sites was specifically performed in downregulated wnt1 (RNAi) genes. b Volcano plot of 72 hR shows the (694) down- and (1409) upregulated genes after wnt1 inhibition, which present fold change (fc) ± 0.5 and p-value adjusted (padj) <0.05 (FDR on lima-voom empirical Bayes moderated t-test). Significant genes are colored light blue, and not significant are colored light red. Some significant genes are labeled. Data provided in Supplementary Data 3. c TF motifs presence on the putative enhancer regions of wnt1 (RNAi) downregulated genes, showing a higher representation of Homeobox. Data provided in Supplementary Data 4. d Gene Ontology (molecular function) analysis of the wnt1 (RNAi) downregulated genes containing TCF binding sites (http://pantherdb.org/). Data provided in Supplementary Data 5. e Schematic illustration of the proposed genetic program activated by wnt1 in posterior wounds.