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. 2023 Jan 18;14:298. doi: 10.1038/s41467-023-35937-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Schematic illustration of Smed-wnt1 gene locus, indicating exons (violet boxes) linked by introns (lines). Genome Browser screenshot showing the ATAC-seq Accessible Chromatin Regions (ACRs), ATAC-seq and H3K27ac ChIP-seq profiles of the putative enhancer regions. Putative Enhancer 1 (E1) and Enhancer 2 (E2) present a FoxG motif (SLP1) (green line). The ATAC-seq peaks corresponding to E1 and the E2 are indicated. b Alignment of WNT1 amino acid sequences show the conservation of the intron 1 position. Yellow line shows the separation between the first and the second exon. c Schematic summary of accessible chromatin regions (ACRs), enhancer activity and FoxG motif evidence in the first intron of wnt1 genes in different eumetazoan species. Green box indicates evidence and white box indicates no available data. Data is provided in Supplementary Data 7. Species used: Homo sapiens (Hsap), Mus musculus (Mmus), Danio rerio (Drer), Xenopus tropicalis (Xtro), Drosophila melanogaster (Dmel), Schmidtea mediterranea (Smed), Macrostumum ligano (Mlig), Hydra vulgaris (Hvul), and Nematostella vectensis (Nvec). Silhouettes are from https://beta.phylopic.org. Xenopus silhouette is from Sarah Werning and the licence is https://creativecommons.org/licenses/by/3.0/. Schmidthea silhouette is from Noah Schlottman and the license is https://creativecommons.org/licenses/by/3.0/.