Table 2.

Relationship between antibodies and demographic factors

Correlation between antibody levels (ELISA) or signal (Western blot) and age/gender indicates that age influences mHTT/HTT antibody levels. Comparison of manifest HD patients and controls revealed no significant differences in antibody levels as measured by ELISA, but a significant increase by Western blot. Using results from manifest HD patients, we performed simple linear regressions to compare antibody levels/signal to CAG repeat length, DBS or stage. *Samples for which zeros were removed as there inclusion resulted in a non-linear data set even after data transformations were applied. p values: as indicated in table

Abbreviations: DBS Disease Burden Score, HD Huntington’s disease

^*Outliers and zeros were removed to allow for a linear model after transformation