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. 2023 Jan 18;14(1):35. doi: 10.1038/s41419-022-05542-w

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Cluster of enriched KEGG pathways obtained using GSEA. Each circle represents an enriched pathway and is colored according to the FDR p value. b Violin plots representing the log₂ (Fold Change) expression for genes with the largest contribution to the GSEA enrichment result per neurodegenerative pathway. c Euler diagram showing ten common downregulated genes between publicly available aging brain gene expression datasets (GSE13120 and GSE48911 accessions in the GEO database) and significantly downregulated mitochondrial genes from this study. d Proposed model of the mitochondrial dysfunction caused by SIRT6 silencing and its involvement in neurodegenerative diseases and normal aging. The figure was generated using the BioRender website.