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. 2023 Jan 18;13:1011. doi: 10.1038/s41598-023-28135-9

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Qgraph plot of spearman correlations (including only absolute values > 0.2 to avoid a crowded figure) adjusted for cohort, sex, age, BMI, creatinine, cotinine and sample storage time. Green lines show positive correlations, red lines show inverse correlations. The color saturation and thickness of lines are proportional to the strength of the correlations. The figure illustrates the data given in Supplementary Table S2. AA: anthranilic acid; CRP: C-reactive protein; HAA: 3-hydroxyanthranilic acid; HK: 3-hydroxykynurenine; KA: kynurenic acid; KTR: kynurenine/tryptophan ratio; Kyn: kynurenine; Neo: neopterin; PLP: pyridoxal 5′-phosphate; Rf: riboflavin; Trp: tryptophan; QA: quinolinic acid; XA: xanthurenic acid.