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. 2023 Jan 5;13:1022567. doi: 10.3389/fphar.2022.1022567

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Copyright © 2023 Li, Zhou, Liao, Tan, Li, Li, Zhou, Bao and He.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The TTC staining of the brain of MCAO rats and the results of 16S rRNA sequencing of the gut microbiota (A) The TTC staining of MCAO rats; (B) The rarefaction curves of Chao1 index; (C) Heatmap of the species compositions; (D) Taxonomic tree in packed circles; (E, F) The linear discriminant analysis (LDA) effect size algorithm (LEfSe) analysis of the gut microbiota. W: MCAO rats with oral administration of warfarin; W-f: pseudo germ-free MCAO rats with oral administration of warfarin; C + W: MCAO rats with oral co-administration of warfarin and Chuanxiong Rhizoma; C + W-f: pseudo germ-free MCAO rats with oral co-administration of warfarin and Chuanxiong Rhizoma. S + W: MCAO rats with oral co-administration of warfarin and senkyunolide I; S + W-f: pseudo germ-free MCAO rats with oral co-administration of warfarin and senkyunolide I.