TABLE 1.

The pharmacokinetics parameters of warfarin (mean ± SD, n = 8).

Group	AUC(0-t) (ng/mL·min)	MRT(0-t) (min)	t1/2z (min)	Tmax (min)	Cmax (ng/ml)
W	1′002′828.4 ± 120′517.3	597.2 ± 97.0	1′108.1 ± 622.5	435.0 ± 588.8	1′281.5 ± 477.6
W-f	1′516′888.9 ± 158′281.2**	597.3 ± 54.3	1′165.8 ± 450.1	216.0 ± 283.3 a	1′724.6 ± 357.1**
C + W	1′716′848.8 ± 67′833.4**	573.5 ± 65.5	1′017.8 ± 590.9	138.0 ± 98.6**	2′124.1 ± 318.7**
C + W-f	1′622′903.9 ± 192′269.7	580.1 ± 23.8	998.0 ± 149.9	105.0 ± 90.0	1′968.4 ± 137.0
S + W	1′654′515.6 ± 394′360.9**	607.0 ± 43.4	1′342.6 ± 514.2	157.0 ± 314.9**	2′106.7 ± 617.1**
S + W-f	1′018′336.1 ± 118′840.5##andand$$	580.0 ± 27.2	1′088.7 ± 952.2	70.0 ± 97.3	1′338.8 ± 272.7##andand$$

^a , compared to the W group, p < 0.05, ** compared to the W group p < 0.01; ##, compared to the S + W group, p < 0.01; andand, compared to the W-f group p < 0.01; $$, compared to the C + W-f group p < 0.01.

W: MCAO, rats with oral administration of warfarin; W-f: pseudo germ-free MCAO, rats with oral administration of warfarin; C + W: MCAO, rats with oral co-administration of warfarin and Chuanxiong Rhizoma; C + W-f: pseudo germ-free MCAO, rats with oral co-administration of warfarin and Chuanxiong Rhizoma; S + W: MCAO, rats with oral co-administration of warfarin and senkyunolide I; S + W-f: pseudo germ-free MCAO, rats with oral co-administration of warfarin and senkyunolide I.