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. 2023 Jan 5;13:1074488. doi: 10.3389/fimmu.2022.1074488

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Copyright © 2023 Cao, Bai, Si, Yan, Zhang, Yisha, Lu, Tuoheti, Guo, Chen, Bai and Liu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original authors(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Kidney injury in the rat model of urinary sepsis (A) Representative images of hematoxylin and eosin (H&E) staining of kidney tissue from the sham and sepsis groups, immunohistochemical analysis of IL-6 and TNF-α in kidney tissue (magnification, 200×; bar, 50 μm). (B, C) Serum BUN and Cre levels in rats 24 hours after E. coli or saline inoculation of the renal pelvis. (D) The relative mRNA levels of IL-6 and TNF-α in kidney tissue. (E) Expressions of IL-6 and TNF-α in kidney tissue were tested by western blot, and β-actin was used as a loading control. (F, G) Quantitative data of the levels of IL-6 and TNF-α. The sep 6× group was selected as a representative of the sepsis groups. Values were shown as mean ± SD. *P < 0.05, **P < 0.01, ***P <0.001, and ****P < 0.0001 vs sham group. "ns" means "not signifcant".