TABLE 2.

Univariate and multivariate Cox regression analysis of clinical characteristics and survival of BC patients in Validation set Cohort.

	Univariate analysis		Multivariate analysis
	HR (95% CI)	p-value	HR (95% CI)	p-value
GSE20685 (OS)
Age	1.006 (0.982–1.031)	0.620	0.999 (0.975–1.023)	0.919
Stage (I/II)	3.141 (1.300–7.590)	0.011	2.835 (1.152–6.978)	0.023
Stage (I/III)	1.077 (0.401–2.895)	0.883	1.191 (0.440–3.223)	0.730
Stage (I/IV)	1.816 (0.795–4.150)	0.157	1.697 (0.735–3.916)	0.216
Risk (High/Low)	0.503 (0.299–0.847)	0.010	0.582 (0.339–0.999)	0.049
GSE21653 (DFS)
Age	1.001 (0.983–1.019)	0.927	0.997 (0.979–1.015)	0.997
Risk (High/Low)	0.444 (0.276–0.716)	0.001	0.439 (0.271–0.710)	0.001
GSE58812 (MFS)
Age	1.061 (1.025–1.098)	0.001	1.054 (1.020–1.089)	0.002
Risk (High/Low)	0.293 (0.125–0.685)	0.005	0.324 (0.138–0.764)	0.010

Abbreviations: HR: hazard ratio; CI: confidence interval; OS: overall survival; DFS: disease-free survival; MFS: metastasis-free survival.