Table 2.
Demographic, clinical and biochemical characteristics in progressors to prediabetes versus nonprogressors.
| Progressor | Nonprogressor | P value | |
|---|---|---|---|
| Number | 111 | 232 | |
| Black/White | 58/53 | 135/97 | 0.30 |
| Women/Men | 65/46 | 180/52 | 0.0003 |
| Premenopausal/ postmenopausal |
35/30 | 115/65 | 0.15 |
| Age (yr) | 47.3 ± 8.94 | 43.8 ± 10.8 | 0.0031 |
| Weight (kg) | 90.0 ± 20.1 | 83.1 ± 21.9 | 0.0051 |
| Baseline BMI (kg/m2) | 31.4 ± 6.88 | 29.6 ± 7.40 | 0.034 |
| Delta BMI (1-yr) (kg/m2) | 0.50 ± 1.48 | 0.16 ± 1.63 | 0.088 |
| Delta BMI (2-yr) (kg/m2) | 0.61 ± 1.85 | 0.30 ± 1.98 | 0.24 |
| FPG (mg/dl) | 94.0 ± 6.75 | 91.0 ± 6.49 | <0.0001 |
| HbA1c (%) | 5.66 ± 0.47 | 5.52 ± 0.43 | 0.0059 |
| BMD (g/cm2) | 1.177± 0.114 | 1.175 ± 0.146 | 0.88 |
| BMC (kg) | 2.60 ± 0.46 | 2.49 ± 0.50 | 0.07 |
| Delta BMD (1-yr) (g/cm2) | -0.02 ± 0.46 | -0.04 ± 0.14 | <0.0001 |
| Trunk fat mass (kg) | 16.6 ± 6.85 | 14.3 ± 7.34 | 0.0079 |
| Total fat mass (kg) | 32.0 ± 1.26 | 29.9 ± 1.40 | 0.19 |
| Insulin sensitivity (µmol/kg FFM.min-1/pM) | 0.12 ± 0.07 | 0.15 ± 0.06 | 0.0014 |
| Insulin secretion (AIR) (µu/ml) | 81.3 ± 73.7 | 88.2 ± 74.2 | 0.44 |
| hsCRP (mg/L) | 4.35 ± 6.67 | 3.55 ± 5.38 | 0.24 |
| Adiponectin (µg/ml) | 8.53 ± 4.35 | 9.87 ± 5.69 | 0.031 |
AIR, acute insulin response to i.v. glucose; BMD, bone mineral density; BMI, body mass index; FFM, fat-free mass; FPG, fasting plasma glucose; hsCRP, high sensitivity C-reactive protein; 2hPG, two-hour plasma glucose; To convert FPG and 2hPG to mmol/l, multiply by 0.56.