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. 2023 Jan 5;14:933453. doi: 10.3389/fnagi.2022.933453

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Copyright © 2023 Decleva, Vidal, Kreuz, de Menezes and Ventura.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Features of the pupillary light reflex. The baseline (B) was obtained as the median of the pupil size of the 3 s before the stimuli. The stimulus (S) was presented as a step of light with 1-s duration. Amplitude (A) was defined as the maximum constriction reached by the pupil after the stimulus. Latency (L) was the time between the beginning of the stimulus and the moment when the pupil reached its maximum constriction. Recovery time was calculated from the pupil maximum constriction until the pupil had returned to 75% of its baseline size (A*0.75). The post-illumination pupil response (PIPR) was calculated as the median pupil size recorded in the period of 6–8 s after the start of the stimulus.