Fig. 3. GR delays Age-associated pathologies with no germline trade-off.
a Paralysis assay showing that GR diets delayed age-associated paralysis in Aβ42 animals (P < 1.0 × 10−10, P value determined by two-tailed Student’s t test). Results from one of three independent experiments are shown. b Survival assay showing that GR diets enhance heat stress resistance of worms at day 5 (P < 1.0 × 10−10, P value determined by two-tailed Student’s t test). Results from representative experiments are shown with additional repeats. c, d Brood size analysis during consecutive generations on the indicated diets (c). GR diets do not reduce F1 brood size (AL diets: n = 5, GR diets: n = 4, P = 0.0532, P value determined by two-tailed Student’s t test) and F2 brood size (AL diets: n = 8, GR diets: n = 7, P = 0.0653, P value determined by two-tailed Student’s t test) (d). Results from representative experiment are shown one of two independent repeats. Error bars indicate mean ± s.d. Source data are provided as a Source Data file.