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. 2023 Jan 18;14:288. doi: 10.1038/s41467-023-35952-z

Fig. 5. GR promotes longevity non-cell autonomously via pro-longevity neuropeptide.

Fig. 5

a Lifespan showing that GR diets extend lifespan of unc-13 (e51) (P < 1.0 × 10−10, P value determined by two-tailed Student’s t test). Results from one of three biological independent experiments are shown. b Lifespan showing that GR diets fail to extend lifespan of unc-31(e928) (P = 0.3647, P value determined by two-tailed Student’s t test). Results from one of three biological independent experiments are shown. c Lifespan showing that GR-induced longevity is significantly shortened in egl-21(n476) animals (P = 0.006, P value determined by two-tailed Student’s t test). Results from one of three biological independent experiments are shown. d Lifespan showing that GR diets extend the lifespan of tdc-1(ok914) mutant animals (P < 1.0 × 10−10, P value determined by two-tailed Student’s t test). Results from one of three biological independent experiments are shown. e Lifespan showing that GR diets extend the lifespan of CRTC-1(S76A, S179A) animals (P < 1.0 × 10−10, P value determined by two-tailed Student’s t test). Results from one of three biological independent experiments are shown. f GR diets do not affect the nuclear/cytoplasmic localization of CRTC-1::RFP and CRTC-1(S76A, S179A)::RFP. Representative images obtained from three biological independent repeats. Source data are provided as a Source Data file.