Table 6.

Morphology result summary for all studies. CCC and RMSE-CV values indicate the agreement between manual ground truth cartilage segmentation volume and the automatic segmentation volumes from both models. DSC values indicate the pixelwise segmentation accuracy of the automatic segmentations from both models compared to the manual ground truth segmentations.

Manual vs. Automatic Morphology Agreement
Study	Tissue	Manual vs. Automatic Volume CCC		Manual vs. Automatic Volume RMSE-CV (%)		DSC (± STD)1
		qDESS Model	OAI-DESS Model	qDESS Model	OAI-DESS Model	qDESS Model	OAI-DESS Model
1: Scanner 1	FC2	0.89	0.13*	2.9	17.7	0.85 (±0.07)	0.66 (±0.07) †
1: Scanner 2	FC	0.84	0.82	4.5	4.9	0.93 (±0.03)	0.70 (±0.05) †
2	FC	0.47*	0.44**	16.1	16.5	0.79 (±0.04)	0.71 (±0.03) †
3	FC	0.71	0.82	12.0	8.2	0.81 (±0.08)	0.71 (±0.09) †
4	FC	0.87	0.84	6.7	7.4	0.88 (±0.04)	0.79 (±0.04) †
4	TC3	0.87	0.55*	6.4	15.0	0.87 (±0.04)	0.69 (±0.06) †
4	PC4	0.95	0.30*	7.1	37.4	0.89 (±0.07)	0.59 (±0.20) †

P-values from Wilcoxon rank-sum tests indicating significant differences between cartilage volume computed using manual and automated segmentation are denoted using the following:

^*<0.01,

^**<0.001.

P-values from Wilcoxon rank-sum tests indicating significant differences between automatic segmentation from the OAI-DESS trained model and the qDESS trained model are denoted using the following:

^†<0.001.

¹STD: Standard Deviation

²FC: Femoral Cartilage

³TC: Tibial Cartilage

⁴PC: Patellar Cartilage