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. 2023 Jan 5;3:1098200. doi: 10.3389/fragi.2022.1098200

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Copyright © 2023 Verschoor, Picard, Andrew, Haynes, Loeb, Pawelec and Kuchel.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Factors associated with GZB and GZK expression in older adults. (A) The log frequency of GZB or GZK-expressing cells and (B) the log mean fluorescence intensity (MFI) of each population was regressed on age, sex, frailty index, CMV serostatus, and plasma TNF and IL-6, while adjusting for site of enrollment. For sex and CMV status, contrasts are males vs. females and positive vs. negative participants, respectively. For all others, coefficients are relative to the magnitude of increase shown in brackets. No overlap of the 95% CI with the red dotted line indicates that the association is significant at the nominal level, while the ‘x’ and ‘#’ indicate that the respective associations for GZB or GZK maintained significance at an FDR adjusted p < .05.