FIGURE 5.

GZK-expressing NK- and CD8 T-cell frequency is inversely associated with prior A/H1N1 antibody titres in older adults. (A) Participants enrolled in the current cohort had also been enrolled in multiple years of a previous randomized vaccine trial, in which A/H1N1 antibody titres against the vaccine strain were measured. (B) Associations for standardized log A/H1N1 antibody titres measured at baseline (i.e., 0) and 4-, 10-, and 20-week post-vaccination, obtained for each year of the randomized trial or all years combined, with standardized log GZK+ NK-cell or CD8⁺ T-cell frequencies obtained in 2018/19. Models for individual years were adjusted for age, sex, vaccine dose, and site of enrollment, whereas models for all years combined were adjusted for age, sex, dose and random intercepts for site, participant and year of study. No overlap of the 95% CI with the red dotted line indicates significance at the nominal level, while the ‘#’ indicates that significance was maintainted at an FDR adjusted p < .05.