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. 2023 Jan 5;13:1068399. doi: 10.3389/fimmu.2022.1068399

Figure 7.

Figure 7

T peripheral helper cells in oligo JIA SF are clonally expanded. (A) UMAP of SF Teffs with known TCR alpha and beta chains from 8 oligo JIA patients, highlighting expanded clonotypes. (B) Percent of expanded clonotypes among total SF Tph (Clusters 4 and 5) or other SF Teff (Clusters 1-3 and 6-10) cells. (C) Heatmap showing the percent of overlap in unique clonotypes between each pair of clusters identified in SF Teffs, split by ANA status. (D) Percent of overlap in unique clonotypes between total PB Teff and SF Tph (Clusters 4 and 5) or other SF Teff (Clusters 1-3 and 6-10) cells. Oligo JIA; oligoarticular juvenile idiopathic arthritis; SF, synovial fluid; PB, peripheral blood; Teff, effector T cell; Tph, T peripheral helper cell; ANA, antinuclear antibody; UMAP, uniform manifold approximation and projection; OXPHOS, oxidative phosphorylation; CTL, cytotoxic lymphocyte. Summary data on bar graphs are mean ± standard error. P-value < 0.01 (**), Statistical testing: two-way ANOVA followed by t-tests on Tph versus other Teff for each subgroup (ANA- and ANA+) with Šídák correction.