Table 2.
Key TCR repertoire metrics from single-cell transcriptomics analysis of SF Teffs.
| Patient | Total SF Teff |
Unique SF Teff |
Max prod freq | Median prod freq (Top 100) |
|---|---|---|---|---|
| JIA1 | 1610 | 1330 | 0.75% | 0.19% |
| JIA2* | 2002 | 1213 | 2.60% | 0.25% |
| p1 | 1882 | 1535 | 0.85% | 0.16% |
| p2* | 1414 | 1090 | 1.13% | 0.21% |
| p3* | 1227 | 1062 | 0.73% | 0.16% |
| p4* | 1530 | 1199 | 0.78% | 0.20% |
| p5 | 1348 | 828 | 12.8% | 0.22% |
| p6 | 1209 | 613 | 9.59% | 0.21% |
*ANA+ oligo JIA patient. Patient IDs reflect those used in the study from which the 10X dataset was extracted (34, 45). Clonal counts and frequencies in the Teff repertoire were computed before exclusion of the contaminating Treg cluster identified in clustering analysis. prod freq, productive frequency. TCR, T cell receptor; SF, synovial fluid, Teff, effector T cell; JIA, juvenile idiopathic arthritis; prod, productive; freq, frequency.