Table 2.
Association between CSF NfL levels (independent variable) with brain volumes and WMH´-s on MRI and cognitive and motor results (dependent variables).
| Pearson correlation coefficient (r), p-value | Age adjusted linear regression Standardized β, p-value | Cohen’s f2 (age adjusted) | |
|---|---|---|---|
| Cerebral grey matter volumes | −0.57 (<0.001*) | −0.487 (0.003*) | 0.52 |
| Cerebral cortex volume | −0.56 (<0.001*) | −0.480 (0.003*) | 0.50 |
| Hippocampus volume | −0.49 (0.003*) | −0.393 (0.021*) | 0.41 |
| WMH total volume | 0.28 (0.105) | 0.208 (0.552) | 0.03 |
| Timed up and go time | 0.53 (0.001*) | 0.437 (0.013*) | 0.55 |
| Gait speed, m/s | −0.45 (0.007*) | −0.358 (0.031) | 0.29 |
| Single-leg stance, sec | −0.28 (0.102) | −0.101 (0.591) | 0.36 |
| Global cognition | −0.40 (0.016*) | −0.311 (0.061) | 0.23 |
| Executive function | −0.40 (0.017*) | −0.318 (0.052) | 0.21 |
| Processing speed | −0.39 (0.022*) | −0.302 (0.066) | 0.19 |
| Memory | −0.46 (0.005*) | −0.348 (0.057) | 0.49 |
WMH, white matter hyperintensities.
*Denotes significance using a false discovery rate of 0.05.