Table 1.
Comparison of eight microbiome profiling studies of Parkinson’s patients
| Author (year) | Sample | Sequencing | Increased in PD Family (genus) |
Decreased in PD Family (genus) |
|---|---|---|---|---|
| Scheperjans, et al (2015) (54) |
Fecal samples (PD n=72; Controls n=72) |
V1-V3 regions 16S rRNA gene. |
• Enterobacteriaceae | • Prevotellaceae |
| Unger, et al (2016) (55) |
Fecal samples (PD n=34; Controls n=34) |
16S rRNA gene | • Enterobacteriaceae | • Prevotellaceae |
| Qian, et al (2018)(56) |
Fecal samples (PD n=45; Controls n=45) |
V3-V4 region of 16S rRNA gene |
• Rikenellaceae (Alistipes), • Prevotellaceae (Paraprevotella) • Enterobacteriaceae (Klebsiella) • Sphingomonadaceae (Sphingomonas) • Moraxellaceae (Acinetobacter) • Comamonadaceae (Aquabacterium) • Desulfovibionaceae (Desulfovibrio) • Clostridiaceae (Clostridium ) • Lachnospiraceae • Oscillospiraceae (Butyricicoccus) • Nitrososphaeraceae (Nitrososphaera) |
• Lactobacillaceae (Lactobacillus) • Chitinophagaceae (Sediminibacterium) |
| Petrovet al. (2017)(61) | Fecal samples (PD n=89; Controls n=66) | 16S rRNA gene |
Christensenellaceae (Christensenell) • Catabacteraceae (Catabacter) • Lactobacillaceae (Lactobacillu) • Oscillospiraceae (Oscillospira, Ruminococcus, Papillibacter) • Bifidobacteriaceae (Bifidobacterium) |
• Lachnospiraceae (Dorea Blautia glucerasea, Coprococcus Eutactus) • Bacteroidaceae (Bacteroides) • Prevotellaceae (Prevotella) • Oscillospiraceae (Faecalibacterium, Ruminococcus callidus) |
| Baldini et al. (2020)(62) |
Fecal samples (PD n=147; Controls n=162) |
16S rRNA gene |
• Verrucomicrobiaceae (Akkermansia.) • Lactobacillaceae • (Lactobacillus) |
• Turicibacteraceae (Turicibacter) • Prevotellaceae (Paraprevotella - female PD) |
| Chiang et al. (2019)(63) | Fecal samples (PD n=80; Controls n=77) | V3-V4 region of the 16S rRNA gene |
• Deferribacteraceae (Mucispirillum), • Porphyromonadaceae (Porphyromonas) • Lactobacillaceae (Lactobacillus), • Tannerellaceae (Parabacteroides) |
• Prevotellaceae (Prevotella) |
| Li, et al (2017)(64) | Fecal samples (PD n=24; Controls n=14) | 16S rRNA gene |
• Enterobacteriaceae (Escherichia, Shigella, Enterococcus) • Streptococcaceae (Streptococcus Proteus) |
• Lachnospiraceae (Blautia) • Oscillospiraceae (Faecalibacterium, Ruminococcus) |
| Hill-Burns E. et al (2017)(65) |
Fecal samples (PD n=197; Controls n=130) |
16S rRNA gene |
• Verrucomicrobiaceae (Akkermansia) • Lactobacillaceae (Lactobacillus) • Bifidobacteriaceae (Bifidobacterium) |
• Lachnospiraceae |