Table 4.
Performances of Candida PCR and BDG used alone and combined for IAC diagnosis.
| Sensitivity% (95%CI) | Specificity% (95%CI) | NPV% (95%CI) | PPV% (95%CI) | Kappa | Value of p | |
|---|---|---|---|---|---|---|
| Positive Candida PCR | 64.7 (38.6–84.7) | 89.4 (78.8–95.3) | 90.8 (80.3–96.2) | 61.1 (36.1–81.7) | 0.529 | <0.001 |
| First positive BDGa | 11.8 (2.1–37.7) | 95.5 (86.4–98.8) | 80.8 (70.0–88.5) | 40.0 (7.3–83.0) | 0.098 | 0.264 |
| Two consecutive positive BDGa,b | 18.2 (3.2–52.2) | 96.2 (78.4–99.8) | 73.5 (55.3–86.5) | 66.7 (12.5–98.2) | 0.181 | 0.144 |
| Positive Candida PCR combining with first positive BDGa | 5.9 (0.3–30.8) | 98.5 (90.7–99.9) | 80.2 (69.6–88.0) | 50.0 (26.7–97.3) | 0.065 | 0.295 |
| Positive Candida PCR combining with two consecutive positive BDGa,b | 9.1 (0.5–42.9) | 100.0 (84.0–100.0) | 72.2 (54.6–85.2) | 100.0 (5.5–100.0) | 0.123 | 0.119 |
Results are presented as n (%). PCR, polymerase chain reaction; BDG, (1–3)-ß-D-glucan; IAC, intra-abdominal candidiasis. aBDG >100 pg/ml was considered positive; b37 patients underwent two consecutive BDG tests.