Table 3.
Main findings of clinical trials investigating circulating asprosin levels and correlations in T2DM.
| Citation | Cohort | Target population (Study group) | n, gender | Main finding & Correlations |
|---|---|---|---|---|
| Zhang et al. (62) | T2DM Case-control design |
Newly diagnosed T2DM (25-70 y) | 170 subjects (101 m, 69 f) T2DM adults (n = 84) NGT (n = 86). |
⇑ Serum asprosin in newly diagnosed T2DM adult patients than NGT group. No significant differences in serum asprosin levels between men and women. |
| Wang et al. (46) | T2DM cross-sectional study |
Newly diagnosed T2DM (27-75 y) | 143 participants T2DM group (n = 51) IGR (n = 40) NGT (n = 52) |
⇑ Plasma asprosin in nT2DM and IGR compared to NGT group especially in IGR participants. |
| Zhang et al. (63) | T2DM | T2DM | 120 participants T2DM patients (n = 60) NGT (n = 60) |
⇑ Fasting asprosin and postprandial asprosin in T2DM patients than in NGT controls. ⇓ Serum asprosin with the onset of the oral glucose tolerance test (75 gm) in NGT group but not in T2DM group. |
| Naiemian set al. (47) | Observational study | New onset T2DM (52-54 y) | 194 adults (100 m, 94 f) Newly diagnosed T2DM (n = 97) Healthy individuals (n = 97) |
⇑ Serum asprosin in T2DM patients compared to healthy group. A positive correlation between asprosin concentrations and insulin resistance (HOMA-IR), TG, hemoglobin A1c (HbA1c), BMI, FBG, TC/HDL-C ratio (atherosclerotic risk factor of cardiovascular diseases) in T2DM patients. |
| Timurkaan et al. (64) | Observational study | Newly diagnosed T2DM | 120 participants T2DM patients (n = 60) (30 m, 30 f) Healthy controls (n = 60) (29 m, 31 f) |
⇑ Asprosin levels in T2DM patients compared to healthy controls. A positive correlation between asprosin levels and BMI, HOMA-IR, insulin, and TG levels in T2DM group. |
| Gozel et al. (20) | Observational study | New diagnosed T2DM treated with metformin | 60 individuals (33 m, 27 f) Newly identified T2DM (n = 30) Healthy volunteers (n = 30) |
⇑ Blood asprosin levels in newly diagnosed T2DM patients compared with the healthy volunteers. ⇓ Blood asprosin levels in newly diagnosed T2DM group after three months treatment with metformin. ⇑ Salivary asprosin levels in newly diagnosed T2DM group. |