. 2023 Jan 5;13:1025242. doi: 10.3389/fmicb.2022.1025242

Table 5.

Association between resistance to ampicillin, tetracycline, erythromycin, chloramphenicol, enrofloxacin, or rifampin and other antimicrobial compounds among Enterococcus spp. isolates using multivariable logistic regression models.

	Enterococcus spp.				Enterococcus faecalis				Enterococcus faecium
	Model^a				Model^a				Model^a
	Adj. OR	95% CI	p-value	Adj. p-value^b	Adj. OR	95% CI	p-value	Adj. p-value^b	Adj. OR	95% CI	p-value	Adj. p-value^b
Resistance to ampicillin
Resistance to tetracycline	5.54	2.90–10.6	<0.001	<0.001
Resistance to erythromycin	8.61	3.75–24.9	<0.001	<0.001	6*10⁷	0-Inf	0.996	0.996	8.69	1.23–173	0.057	0.083
Resistance to chloramphenicol	0.25	0.05–0.88	0.047	0.075
Resistance to enrofloxacin	20.4	6.04–128	<0.001	<0.001
Resistance to rifampin	1.69	0.94–3.19	0.088	0.114	5*10⁷	0-Inf	0.996	0.996	3*10⁷	0-Inf	0.991	0.996
Resistance to tetracycline
Resistance to ampicillin	5.67	2.99–10.8	<0.001	<0.001
Resistance to erythromycin	2.98	1.57–6.10	0.002	0.004	3.44	1.49–9.36	0.007	0.015
Resistance to chloramphenicol	62.6	19.5–282	<0.001	<0.001	207	38.7–3869	<0.001	<0.001	10.9	1.21–234	0.049	0.075
Resistance to enrofloxacin	0.30	0.17–0.52	<0.001	<0.001	0.23	0.12–0.46	<0.001	<0.001
Resistance to rifampin	0.31	0.19–0.52	<0.001	<0.001	0.42	0.21–0.82	0.011	0.020	0.19	0.07–0.48	<0.001	0.001
Resistance to erythromycin
Resistance to ampicillin	8.77	3.85–25.3	<0.001	<0.001	10⁷	0-Inf	0.991	0.996	8.69	1.23–173	0.057	0.083
Resistance to tetracycline	2.66	1.43–5.32	0.003	0.007	3.35	1.47–9.04	0.008	0.015
Resistance to chloramphenicol	4*10⁶	0-Inf	0.974	0.996	3*10⁶	0-Inf	0.978	0.996
Resistance to enrofloxacin									17.5	2.62–162	0.005	0.010
Resistance to rifampin					0.64	0.41–0.98	0.045	0.074
Resistance to chloramphenicol
Resistance to ampicillin	0.24	0.05–0.84	0.040	0.067
Resistance to tetracycline	61.7	19.4–278	<0.001	<0.001	225	41.5–4212	<0.001	<0.001	9.21	1.13–190	0.059	0.083
Resistance to erythromycin	2*10⁷	0-Inf	0.987	0.996	4*10⁷	0-Inf	0.992	0.996
Resistance to enrofloxacin	2.23	0.80–6.78	0.137	0.165	2.88	0.93–9.52	0.072	0.097
Resistance to rifampin
Resistance to enrofloxacin
Resistance to ampicillin	21.1	6.28–132	<0.001	<0.001					3*10⁸	0-Inf	0.994	0.996
Resistance to tetracycline	0.34	0.21–0.56	<0.001	<0.001	0.23	0.12–0.45	<0.001	<0.001	0.12	0.01–1.19	0.091	0.114
Resistance to erythromycin									26.4	3.10–581	0.007	0.015
Resistance to chloramphenicol					2.42	0.78–8.02	0.134	0.164
Resistance to rifampin	2.66	1.84–3.84	<0.001	<0.001	2.82	1.86–4.29	<0.001	<0.001
Resistance to rifampin
Resistance to ampicillin	1.70	0.97–3.14	0.074	0.097
Resistance to tetracycline	0.35	0.22–0.56	<0.001	<0.001	0.47	0.26–0.85	0.012	0.022	0.21	0.08–0.54	0.001	0.003
Resistance to erythromycin					0.66	0.42–1.01	0.062	0.085
Resistance to chloramphenicol
Resistance to enrofloxacin	2.61	1.81–3.77	<0.001	<0.001	2.86	1.88–4.35	<0.001	<0.001	MP	1.20–60.8	0.036	0.063

The model started with ampicillin, tetracycline, erythromycin, chloramphenicol, enrofloxacin, and rifampin before backwards selection; selected antimicrobials regularly tested on Enterococcus spp. isolates were entered in the model as explanatory variables.

p-values were adjusted according to Benjamini and Hochberg (1995). Values >10¹⁰⁰ and <0.01 are mentioned as Inf and 0, respectively.

Bold values are significant results (p<0.05 after Benjamini and Hochberg adjustment).