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. 2023 Jan 5;13:1050373. doi: 10.3389/fimmu.2022.1050373

Table 3.

Clinical characteristics of BP cases treated by biologics.

Ref. Age/sex PASI Medication history Biologics treatment Dose Course of treatment Anti-BP180/BP230 EOS Outcome of BP
(24) 57/M ND Cyclosporin, topical corticosteroids and calcipotriol Etanercept 50 mg qw 6 months Anti-BP180: 175 U/ml ND CR
(25) 49/F 17.2 Cyclosporine, methotrexate
and NB/UVB phototherapy
Etanercept 100 mg qw 12 weeks ND ND CR
(26) 64/M 12 Psoralen, ultraviolet A light therapy and topical corticosteroids Etanercept 50 mg qw then 50 mg biw ND ND ND CR
(27) 88/F 6.4 Acitretin Ustekinumab 45 mg at week 0 and week 4, then every 12
weeks
48 months Anti-BP180: 17 U/ml and anti-BP230: 103 U/ml 700/µl CR
(28) 37/F 11.6 Topical corticosteroids Ixekizumab 160 mg at week 0, then 80 mg at weeks 2, 4, 6, 8, 10, and 12, then 80 mg every 4 weeks 1 year Anti-BP180: 21 U/ml and anti-BP230: 52 U/ml ND CR
(29) 68/M 48.5 Intermittent courses of methotrexate, acitretin, cyclosporin, phototherapy and topical therapies Secukinumab 300 mg at weeks 1, 2, 3, and 4 and then 300 mg every 4 weeks 7 months ND 400/µl CR
(30) 85/F No history of psoriasis ND Secukinumab 300 mg at days 1, 8, 15, 22, 50, and 83 12 weeks Anti-BP180: 689 U/ml ND CR

BP, bullous pemphigoid; Ref, reference; PASI, Psoriasis area and severity index; EOS, eosinophil; qw, once a week; biw, twice a week; CR, complete remission; ND, not described; F, female; M, male.