Table 3.
Clinical characteristics of BP cases treated by biologics.
Ref. | Age/sex | PASI | Medication history | Biologics treatment | Dose | Course of treatment | Anti-BP180/BP230 | EOS | Outcome of BP |
---|---|---|---|---|---|---|---|---|---|
(24) | 57/M | ND | Cyclosporin, topical corticosteroids and calcipotriol | Etanercept | 50 mg qw | 6 months | Anti-BP180: 175 U/ml | ND | CR |
(25) | 49/F | 17.2 | Cyclosporine, methotrexate and NB/UVB phototherapy |
Etanercept | 100 mg qw | 12 weeks | ND | ND | CR |
(26) | 64/M | 12 | Psoralen, ultraviolet A light therapy and topical corticosteroids | Etanercept | 50 mg qw then 50 mg biw | ND | ND | ND | CR |
(27) | 88/F | 6.4 | Acitretin | Ustekinumab | 45 mg at week 0 and week 4, then every 12 weeks |
48 months | Anti-BP180: 17 U/ml and anti-BP230: 103 U/ml | 700/µl | CR |
(28) | 37/F | 11.6 | Topical corticosteroids | Ixekizumab | 160 mg at week 0, then 80 mg at weeks 2, 4, 6, 8, 10, and 12, then 80 mg every 4 weeks | 1 year | Anti-BP180: 21 U/ml and anti-BP230: 52 U/ml | ND | CR |
(29) | 68/M | 48.5 | Intermittent courses of methotrexate, acitretin, cyclosporin, phototherapy and topical therapies | Secukinumab | 300 mg at weeks 1, 2, 3, and 4 and then 300 mg every 4 weeks | 7 months | ND | 400/µl | CR |
(30) | 85/F | No history of psoriasis | ND | Secukinumab | 300 mg at days 1, 8, 15, 22, 50, and 83 | 12 weeks | Anti-BP180: 689 U/ml | ND | CR |
BP, bullous pemphigoid; Ref, reference; PASI, Psoriasis area and severity index; EOS, eosinophil; qw, once a week; biw, twice a week; CR, complete remission; ND, not described; F, female; M, male.