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BoNTs targets at nervous endings and their different sites of cleavage according to toxin types.
| BoNT type | Target | Peptide bond cleaved |
|---|---|---|
| A | SNAP25 | Q197R198 |
| B | VAMP 1–3 | Q76F77 |
| C and C/D | SNAP25 | R198A199 |
| Syntaxin-1A | K253A254 | |
| Syntaxin-1B | K252A253 | |
| D and D/C | VAMP | K49I50 |
| E | SNAP25 | R180I181 |
| F | VAMP 1–3 | Q48K49 |
| VAMP 2 | Subtype F5: L54E55 | |
| G | VAMP 1–3 | A82A83 |
| H | VAMP 1–3 | L54E55 |
| X | VAMP 2–5 | R66A67 |
