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Transcription factors regulating MN development in vivo and their use in differentiating iPSCs into MNs in vitro. (A) Transcription factors expressed in the MN progenitors (pMN) and post-mitotic MNs (MN) in the developing neural tube. (B) Representative protocol for using expression of specific transcription factors to direct the differentiation of iPSCs into MNs. Created with BioRender.com.
