Table 3.
SHR status in relation with neurological function outcomes, mortality or hemorrhage in participants with and without diabetes.
| Outcomes | Q1 | Q2 | Q3 | Q4 | p interaction | OR (95%CI) | p value | OR (95%CI) | p value | OR (95%CI) | p value | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Excellent outcomes at 3 months (mRS 0–1) | Diabetesa1 (n = 37) | Reference | 0.57 [0.17; 1.85] | 0.354 | 0.32 [0.06; 1.34] | 0.133 | 0.39 [0.11; 1.26] | 0.121 | 0.962 | ||||||
| Without diabetesa2 (n = 102) | Reference | 0.39 [0.17; 0.88] | 0.025* | 0.37 [0.15; 0.86] | 0.022* | 0.32 [0.11; 0.83] | 0.023* | ||||||||
| Good outcomes at 3 months (mRS 0–2) | Diabetesb1 (n = 60) | Reference | 0.65 [0.19; 2.12] | 0.477 | 0.32 [0.08; 1.23] | 0.105 | 0.28 [0.08; 0.88] | 0.034* | 0.498 | ||||||
| Without diabetesa2 (n = 79) | Reference | 0.54 [0.24; 1.20] | 0.135 | 0.69 [0.31; 1.55] | 0.379 | 0.55 [0.22; 1.38] | 0.207 | ||||||||
| Major neurological improvement | Diabetesc1 (n = 57) | Reference | 0.77 [0.26; 2.22] | 0.635 | 0.51 [0.15; 1.60] | 0.250 | 0.45 [0.16; 1.27] | 0.135 | 0.478 | ||||||
| Without diabetesa2 (n = 82) | Reference | 0.69 [0.33; 1.43] | 0.329 | 0.45 [0.21; 0.97] | 0.043* | 0.52 [0.22; 1.21] | 0.135 | ||||||||
| All-cause mortality at 3 months | Diabetesd1 (n = 26) | Reference | 0.70 [0.11; 4.23] | 0.685 | 1.13 [0.22; 6.56] | 0.881 | 2.34 [0.62; 11.47] | 0.239 | 0.244 | ||||||
| Without diabetesd1 (n = 113) | Reference | 1.82 [0.51; 7.49] | 0.367 | 0.62 [0.14; 2.82] | 0.524 | 1.20 [0.30; 5.26] | 0.790 | ||||||||
| ICH | Diabetese1 (n = 36) | Reference | 1.23 [0.31; 5.33] | 0.762 | 1.39 [0.33; 6.25] | 0.650 | 2.63 [0.80; 10.41] | 0.129 | 0.468 | ||||||
| Without diabetese2 (n = 103) | Reference | 2.06 [0.87; 5.10] | 0.104 | 3.11 [1.34; 7.67] | 0.009** | 2.56 [0.99; 6.83] | 0.053 | ||||||||
| sICH | Diabetesf1 (n = 10) | Reference | 3.26 [0.44; 66.22] | 0.303 | 0.97 [0.03; 25.66] | 0.987 | 2.29 [0.32; 46.16] | 0.469 | 0.302 | ||||||
| Without diabetesf1 (n = 129) | Reference | - | 0.990 | - | 0.989 | - | 0.989 | ||||||||
*p < 0.05, **p < 0.01, ***p < 0.001. CI indicates confidence interval; SHR, stress hyperglycemia ratio; OR, odds ratio; ICH, intracranial hemorrhage and sICH, symptomatic intracranial hemorrhage. a1Adjusted for age, NIHSS score at admission, pre-stroke mRS. a2Adjusted for age, sex, previous TIA/stroke, history of hypertension, NIHSS score at admission, pre-stroke mRS, systolic blood pressure and IV tPA administration. b1Adjusted for age, previous TIA/stroke, NIHSS score at admission, pre-stroke mRS and IV tPA administration. c1Adjusted for age, NIHSS score at admission, pre-stroke mRS, onset-to-reperfusion time and IV tPA administration. d1Adjusted for age and NIHSS score at admission. e1Adjusted for NIHSS score at admission and IV tPA administration. e2Adjusted for age, hypertension, systolic blood pressure, NIHSS score at admission, pre-stroke mRS and IV tPA administration. f1Adjusted for IV tPA administration.