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. 2023 Jan 5;9:988529. doi: 10.3389/fnut.2022.988529

FIGURE 1.

FIGURE 1

Prebiotic administration to mothers sensitises their offspring to colitis. Impact of prebiotic administration to mothers was measured in offspring during and at the end of a protocol of colitis induction by dextran sulphate sodium (DSS) in all groups of mice. Pups of mothers fed with a standard diet were administered DSS (in blue) or left untouched (in green). The same procedure was followed for pups of mothers fed a diet enriched with prebiotics (P + DSS in pink, P in orange). (A) Weight curves of the animals, where the weight was normalised as per the weight on the first day of DSS treatment (D1) for each mouse. N = 28–30 mice/group. (B) Survival curves of mice. N = 26–30 mice/group. (C) DAI was measured before (D-1) and on D4, D11, D18 of the protocol. N = 29–30 mice/group. (D) Faeces humidity for each mouse. N = 16–28 mice/group. Data represent the mean and standard deviation of the mean. Log-rank test for the survival rate or two-way analysis of variance (ANOVA), followed by Bonferroni’s post hoc comparisons tests: *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, blue asterisk for P + DSS vs. DSS, orange for P + DSS vs. P, and green for DSS vs. C groups.