Table 2.
Univariate and Multivariate Analyses of Prognostic Factors Associated with the Early Recurrence of HCC
| Characteristic | Comparison | Univariate | Multivariate | ||||
|---|---|---|---|---|---|---|---|
| HR | 95% CI | P-value | HR | 95% CI | P-value | ||
| Sex | Male vs female | 0.990 | 0.536–1.829 | 0.975 | |||
| Age, year | ≥45 vs <45 | 0.738 | 0.477–1.142 | 0.173 | |||
| BMI, kg/m2 | ≥24 vs <24 | 0.543 | 0.330–0.894 | 0.016 | 0.908 | 0.514–1.601 | 0.738 |
| Diabetes mellitus | Yes vs no | 0.681 | 0.275–1.683 | 0.405 | |||
| HBsAg | Positive vs negative | 1.256 | 0.578–2.727 | 0.565 | |||
| HBV-DNA, 102 IU/mL | ≥5 vs <5 | 0.963 | 0.604–1.536 | 0.874 | |||
| Child-Pugh class | A stage vs B stage | 1.071 | 0.337–3.397 | 0.908 | |||
| Total bilirubin, µmol/L | ≥17.1 vs <17.1 | 0.772 | 0.472–1.259 | 0.300 | |||
| ALB, mg/L | ≥35 vs <35 | 1.033 | 0.516–2.067 | 0.927 | |||
| ALT, U/L | ≥40 vs <40 | 0.737 | 0.474–1.147 | 0.176 | |||
| AST, U/L | ≥40 vs <40 | 1.359 | 0.875–2.111 | 0.172 | |||
| PT, s | ≥13 vs <13 | 1.519 | 0.980–2.353 | 0.061 | 1.149 | 0.705–1.871 | 0.578 |
| INR | ≥1 vs <1 | 1.208 | 0.715–2.041 | 0.479 | |||
| Platelet count, 109 /L | ≥225 vs <225 | 1.673 | 1.078–2.596 | 0.022 | 1.679 | 1.022–2.757 | 0.041 |
| CTCs, n/5mL | >5 vs ≤5 | 3.324 | 1.994–5.539 | 0.000 | 2.467 | 1.430–4.258 | 0.001 |
| AFP, µg/mL | ≥200 vs <200 | 1.949 | 1.220–3.112 | 0.005 | 1.136 | 0.672–1.921 | 0.635 |
| Tumor size, cm | ≥5 vs <5 | 2.222 | 1.300–3.799 | 0.004 | 1.190 | 0.664–2.134 | 0.560 |
| Multiple lesions | Yes vs no | 1.671 | 1.056–2.645 | 0.028 | 1.392 | 0.805–2.406 | 0.237 |
| Inflow blood occlusion | Yes vs no | 1.162 | 0.701–1.926 | 0.561 | |||
| Tumor capsule | Complete vs incomplete | 0.593 | 0.357–0.984 | 0.043 | 0.589 | 0.336–1.030 | 0.063 |
| Resection margin, cm | ≥1 vs.<1 | 1.332 | 0.839–2.116 | 0.224 | |||
| MVI | Positive vs negative | 3.758 | 2.191–6.445 | 0.000 | 2.580 | 1.413–4.709 | 0.002 |
| Histological grade | ≥3 vs <3 | 0.830 | 0.535–1.289 | 0.406 | |||
| Histological cirrhosis | Yes vs no | 0.875 | 0.554–1.384 | 0.569 | |||
| Satellite nodule | Yes vs no | 1.902 | 1.155–3.132 | 0.012 | 1.196 | 0.673–2.126 | 0.542 |
| Ki67 | ≥35% vs <35% | 2.135 | 1.373–3.320 | 0.001 | 1.544 | 0.942–2.532 | 0.085 |
| Postoperative adjuvant therapy | Yes vs no | 1.192 | 0.770–1.847 | 0.431 | |||
Abbreviations: AFP, alpha-fetoprotein; ALB, albumin; ALT, alanine aminotransferase; AST, aspartate aminotransferase; BMI, body mass index; CI, confidence interval; CTCs, circulating tumor cell; HBV-DNA, hepatitis B virus DNA; HBsAg, hepatitis B surface antigen; HR, hazard ratio; INR, international normalized ratio; MVI, microvascular invasion; PT, prothrombin time.