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. 2023 Jan 3;18:100534. doi: 10.1016/j.mtbio.2022.100534

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© 2022 Published by Elsevier Ltd.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 4 — Mechanism of overcoming drug resistance. (A) Confocal fluorescent images of MuRSA after 2 h and 6 h of incubation with TPGS/Mup-Ag and Mup-Ag. (B) Quantitative analysis of fluorescence in (A) with imageJ. (C) Expression levels of NorA mRNA transcripts of MuRSA treated with different preparations for 20 h assessed by RT-PCR. Untreated MuRSA was used as a control. (D) Confocal fluorescent images of MuRSA after exposure to EB for 4 h, following pretreatment with TPGS and CCCP (n = 3). (E) Quantitative analysis of the increase in EB accumulation compared with the negative control groups (n = 3). Data are presented as the mean ± SD: ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001.