Table 3.
Genotype distribution and allele frequencies of the MICA SNP (rs2596542) in the cholangiocarcinoma (CCA) and control groups
| Parameter | CCA (n = 40) | Control (n = 45) | χ2 (p1) | OR | 95% CI | p 2 | |||
|---|---|---|---|---|---|---|---|---|---|
| n | % | n | % | ||||||
| Genotypes | |||||||||
| CC® | 13 | 32.5 | 22 | 48.9 | 6.490* (0.039*) | 1.000 | |||
| CT | 11 | 27.5 | 16 | 35.6 | 1.163 | 0.416-3.257 | 0.773 | ||
| TT | 16 | 40.0 | 7 | 15.6 | 3.868 | 1.260-11.880 | 0.018* | ||
| HWχ2 (p0) | 1.800 (0.180) | ||||||||
| Dominant model | |||||||||
| CC® | 13 | 32.5 | 22 | 48.9 | 2.348 (0.125) | 1.000 | |||
| CT+ TT | 27 | 67.5 | 23 | 51.1 | 1.987 | 0.822-4.803 | 0.128 | ||
| Recessive model | |||||||||
| CC+ CT® | 24 | 60.0 | 38 | 84.4 | 6.411* (0.011*) | 1.000 | |||
| TT | 16 | 40.0 | 7 | 15.6 | 3.619 | 1.299-10.084 | 0.014* | ||
| Allele | |||||||||
| C® | 37 | 46.3 | 60 | 66.7 | 7.205* (0.007*) | 1.000 | |||
| T | 43 | 53.8 | 30 | 33.3 | 2.324 | 1.250-4.324 | 0.007* | ||
χ2, p1 – chi-squared test, OR – odds ratio, CI – confidence interval, LL – lower limit, UL – upper limit, ® reference group, p2 – p value for comparing between the studied groups
HW
χ2 (p0): chi-squared for goodness of fit for Hardy-Weinberg equilibrium (if p < 0.05, not consistent)
*
Statistically significant at p < 0.05