Table 4.
Comparison of genotype and allele frequencies of rs58542926 between HCC patients, CLD and control group
| Polymorphism data | Group I (n = 40) | Group II (n = 40) | Group III (n = 40) | P | Significance between groups | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| n | % | n | % | n | % | I vs. II | I vs. III | II vs. III | ||
| Additive genetic model | ||||||||||
| CC | 12 | 30.0 | 28 | 70.0 | 38 | 95.0 | MCp< 0.001* | 0.001* | MCp< 0.001* | MCp 0.008* |
| CT | 20 | 50.0 | 10 | 25.0 | 2 | 5.0 | ||||
| TT | 8 | 20.0 | 2 | 5.0 | 0 | 0.0 | ||||
| OR (95% CI) | *I and II CC reference CT: 4.67 [1.67-12.90] TT: 9.33 [1.72-50.61] | *I and III CC reference CT: 31.68 [6.45-155.6] TT: – | ||||||||
| Recessive genetic model | ||||||||||
| CT + CC | 32 | 80.0 | 38 | 95.0 | 40 | 100.0 | MCp= 0.005* | 0.043* | FEp= 0.005* | FEp= 0.494 |
| TT | 8 | 20.0 | 2 | 5.0 | 0 | 0.0 | ||||
| OR (95%CI) | *I and II 4.75 [0.94-23.98] | *I and III – | ||||||||
| Dominant genetic model | ||||||||||
| CC | 12 | 30.0 | 28 | 70.0 | 38 | 95.0 | MCp< 0.001* | < 0.001* | < 0.001* | 0.003* |
| CT + TT | 28 | 70.0 | 12 | 30.0 | 2 | 5.0 | ||||
| OR (95%CI) | *I and II 5.44 (2.09-14.17) | *I and III 44.33 (9.18-214.06) | ||||||||
| Alleles | ||||||||||
| C | 44 | 55.0 | 66 | 82.5 | 78 | 97.5 | < 0.001* | 0.001* | < 0.001* | 0.006* |
| T | 36 | 45.0 | 14 | 17.5 | 2 | 2.5 | ||||
| OR (95% CI) | *I and II 3.86 (1.87-7.97) | *I and III 31.909 (7.33-138.93) | ||||||||
| HWE | p | 0.87 | ||||||||
| χ2 | 0.026 | |||||||||
HWE – p value for Hardy-Weinberg, χ2 – chi-square test, MC – Monte Carlo
p – p value for comparing between the studied groups, FE – Fisher exact
OR – odds ratio, CI – confidence interval, LL – lower limit, UL – upper limit
*
Statistically significant at p < 0.05