TABLE 1.
Salivary antibody responses to MenA and MenC PS after primary immunization with MACconj or MACPSa
| Antibody | Time (days) after primary vaccination | Group 1 (MACconj)
|
Group 2 (MACPS)
|
Pb | ||
|---|---|---|---|---|---|---|
| Antibody level in saliva (ng/ml) (95% CI) | No. of subjects | Antibody level in saliva (ng/ml) (95% CI) | No. of subjects | |||
| MenA IgG | 0 | 9.92 (6.96, 14.08) | 88 | 15.60 (11.40, 21.40) | 86 | NSf |
| 30 | 31.24c (20.50, 47.50) | 88 | 46.26c (32.39, 66.10) | 86 | NS | |
| MenA IgA | 0 | 40.81 (27.18, 61.28) | 87 | 49.26 (32.92, 73.71) | 85 | NS |
| 30 | 67.75d (46.30, 99.15) | 87 | 126.91c (87.42, 183.70) | 85 | <0.05 | |
| MenC IgG | 0 | 6.88 (5.10, 9.30) | 88 | 8.17 (6.00, 11.12) | 86 | NS |
| 30 | 15.69c (10.73, 23.0) | 88 | 22.44c (15.64, 32.20) | 86 | NS | |
| MenC IgA | 0 | 9.44 (6.95, 12.82) | 87 | 7.25 (5.33, 9.85) | 85 | NS |
| 30 | 8.90e (6.56, 12.05) | 87 | 33.81c (24.55, 46.57) | 85 | <0.001 | |
a
Data on the subjects who completed the primary phase of the study and for whom saliva samples were analyzed for each antibody type are presented.
b
P values of comparisons of antibody concentrations between two vaccines at each time point.
c
P < 0.001 (between the day 0 and day 30 results).
d
P < 0.01 (between the day 0 and day 30 results).
e
P = NS (between the day 0 and day 30 results).
f
NS, not significantly different.