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. 2022 Dec 22;7(1):e10705. doi: 10.1002/jbm4.10705

Table 4.

Fracture Healing Outcomes over 12 Months

Adjusted mean difference a (80% CI) p value
Hypothesis 1—High dose versus low dose
FIX‐IT score 0.59 (−0.17, 1.36) 0.32
RUST score 0.51 (−0.22, 1.24) 0.37
Hypothesis 2—High loading dose versus high daily dose
FIX‐IT score 0.44 (−0.44, 1.31) 0.52
RUST score −0.19 (−1.01, 0.62) 0.76
Hypothesis 3—Low dose versus placebo dose
FIX‐IT score 0.28 (−0.79, 0.93) 0.73
RUST score −0.55 (−1.40, 0.29) 0.40
Post hoc analysis 1—Any vitamin D dose versus placebo dose
FIX‐IT score 0.70 (−0.08, 1.48) 0.25
RUST score −0.21 (−0.86, 0.44) 0.68
Post hoc analysis 2—High dose versus placebo dose
FIX‐IT score 0.89 (0.05, 1.74) 0.18
RUST score −0.04 (−0.73, 0.63) 0.93

CI = confidence interval; FIX‐IT = function index for trauma; RUST = radiographic union score for tibial fractures; SD = standard deviation.

a

Analysis adjusted for fracture location (tibia versus femur).