Fig. 7.

Micro‐CT analysis of dentoalveolar complex from adult hypophosphatasia (HPP) mice and wild‐type (WT) littermates. 2D and 3D micro‐CT images of (A–D) first molar (M1) and incisor (INC) from AAV8‐TNAP‐D₁₀‐ or AAV8‐GFP‐treated mice 60 days after injection. (E) Quantification of molar enamel, dentin, alveolar bone, and pulp parameters. (F) Quantification of incisor enamel and dentin volumes and densities. (G–J) Hematoxylin and eosin (H&E) staining of tissue organization of teeth. No obvious difference in tissue organization, periodontal attachments, or acellular cementum between AAV8‐TNAP‐D₁₀‐ or AAV8‐GFP‐treated mice. Statistical analysis was performed by one‐way ANOVA followed by Tukey's multiple comparison test. Differences were statistically significant at *p < 0.05. AB = alveolar bone; CC = cellular cementum; CEJ = cemento‐enamel junction; DE = dentin; EN = enamel; PDL = periodontal ligaments.