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. Author manuscript; available in PMC: 2023 Jan 19.
Published in final edited form as: Cell Rep. 2022 Dec 13;41(11):111835. doi: 10.1016/j.celrep.2022.111835

Figure 6. De novo PBP mutations occur infrequently and do not persist in vivo under penicillin selective pressure.

Figure 6.

Data points represent the total CFU recovered from the lungs of infected mice for three separate lineages of passaged pneumococcal strains. The corresponding penicillin dose given to each mouse is labeled above the data points and incrementally increased with successive generations. Whole-genome sequencing confirmed the presence of PBP mutations. Colored points represent pneumococcal populations containing one or more mutations in PBP genes. SNPs and SNP frequencies for the respective PBP genes are listed in the legend.