Table 3.
Summary of BS LIV–VI aIC-BLA intrinsic properties
| Groups | RMP (mV) |
fAHP (mV) |
mAHP (mV) |
sAHP (mV) |
Input resistance (MΩ) |
Sag ratio (%) |
Time constant (ms) |
AP thresh (mV) |
AP Amp (mV) |
AP half-width (ms) |
Rheobase (pA) |
|---|---|---|---|---|---|---|---|---|---|---|---|
| BS LIV–VI aIC-BLA Cage Control |
−68.28 ± 0.9705 (13) |
9.192 ± 2.061 (13) |
−4.194 ± 0.5072 (13) |
−2.075 ± 0.4500 (13) |
118.4 ± 9.771 (13) |
14.91 ± 2.195 (13) |
14.71 ± 1.944 (13) |
−31.83 ± 2.971 (13) |
56.27 ± 1.147 (13) |
0.6692 ± 0.05460 (13) |
74.54 ± 8.471 (13) |
| BS LIV–VI aIC-BLA Water |
−69.00 ± 1.639 (11) |
7.800 ± 1.607(11) | −4.870 ± 0.8838 (11) |
−2.826 ± 0.6069 (11) |
136.5 ± 14.40 (11) |
8.751 ± 2.021 (11) |
18.03 ± 2.309 (11) |
−29.27 ± 2.060 (11) |
54.21 ± 1.572 (11) |
0.6736 ± 0.03111 (11) |
85.91 ± 13.44 (11) |
| BS LIV–VI aIC-BLA Saccharin 1x |
−68.80 ± 1.065 (17) |
2.870 ± 1.044 (17) |
−4.339 ± 0.5083 (17) |
−2.564 ± 0.3032 (17) |
146.6 ± 14.22 (17) |
11.67 ± 1.790 (17) |
14.27 ± 1.666 (17) |
−30.73 ± 2.385 (17) |
51.64 ± 1.473 (17) |
0.5976 ± 0.03555 (17) |
63.65 ± 7.679 (17) |
| BS LIV–VI aIC-BLA Quinine 1x |
−67.37 ± 1.682 (9) |
13.67 ± 2.681(9) ## | −6.131 ± 0.6514 (8) |
−3.58 ± 0.5788 (8) |
139.2 ± 16.86 (9) |
14.15 ± 2.159 (9) |
23.21 ± 2.717 (9) |
−29.35 ± 3.071 (9) |
58.86 ± 2.003 (9) |
0.6378 ± 0.0491 (9) |
59.56 ± 12.28 (9) |
| BS LIV–VI aIC-BLA Saccharin 5x |
−67.20 ± 1.624 (10) |
11.30 ± 1.727 (10) ## |
−5.174 ± 0.8427 (10) |
−3.609 ± 0.7205 (10) |
156.1 ± 22.85 (10) |
11.92 ± 3.395 (10) |
17.11 ± 2.296 (10) |
−30.38 ± 2.493 (10) |
58.40 ± 1.812 (10) |
0.7140 ± 0.07349 (10) |
76.60 ± 15.32 (10) |
| BS LIV–VI aIC-BLA Saccharin 1x (4 h) |
−68.20 ± 1.293 (6) |
3.433 ± 0.9245(6) | −6.693 ± 1.442 (6) |
−3.130 ± 1.637 (6) |
154.9 ± 22.41(6) | 14.99 ± 2.770 (6) |
26.09 ± 5.331 (6) |
−34.61 ± 2.174 (6) |
46.79 ± 4.359 (6) |
0.8850 ± 0.05943 (6) # |
60.83 ± 11.36 (6) |
| BS LIV–VI aIC-BLA Saccharin 2x |
−71.33 ± 1.641 (13) |
4.169 ± 0.9225 (13) |
−5.368 ± 0.9616 (13) |
−3.226 ± 0.4899 (13) |
180.3 ± 15.15 (13) ** |
7.017 ± 1.317 (13) *** |
19.77 ± 2.447 (13) |
−34.20 ± 1.987 (13) |
46.18 ± 1.666 (13) *** |
0.5331 ± 0.03522 (13) |
77.54 ± 15.69 (13) |
| BS LIV–VI aIC-BLA CTA Retrieval |
−67.37 ± 1.21 (12) |
5.473 ± 1.464 (12) |
−4.633 ± 0.5831 (12) |
−1.932 ± 0.4462 (12) |
110.9 ± 12.98 (12) |
16.8 ± 1.869 (12) |
17.06 ± 2.608 (12) |
−34.28 ± 1.771 (12) |
57.87 ± 1.678 (12) |
0.6367 ± 0.03961 (12) |
88.75 ± 9.847 (12) |
| BS LIV–VI aIC-BLA Extinction |
−67.36 ± 1.43 (11) |
3.943 ± 1.111 (11) |
−4.816 ± 0.8447 (11) |
−2.104 ± 0.4466 (11) ∼ |
131.1 ± 13.93 (11) |
13.69 ± 1.541 (11) |
14.52 ± 2.714 (11) ∼ ∼ |
−37.41 ± 1.636 (11) ∼ ∼ |
57.3 ± 2.023 (11) |
0.7155 ± 0.03674 (11) |
81 ± 6.932 (11) |
| BS LIV–VI aIC-BLA Reinstatement |
−68.88 ± 1.163 (10) |
6.432 ± 1.737 (10) |
−5.243 ± 0.5853 (10) |
−3.804 ± 1.339 (10) |
157.4 ± 10.56 (10) |
9.124 ± 1.03 (10) |
26.93 ± 1.893 (10) |
−27.5 ± 2.195 (10) |
57.36 ± 3.001 (10) |
0.769 ± 0.03494 (10) |
73.9 ± 12.45 (10) |
Values are expressed in mean ± SEM. The number of cells is in parentheses. Statistical analysis was performed by one-way ANOVA post hoc Tukey’s and Dunn’s multiple comparisons. Student’s t test was performed for the comparison between two groups. RMP, resting membrane potential; fAHP, mAHP, and sAHP, fast, medium, and slow after hyperpolarization potentials, respectively; AP Thresh, action potential threshold; AP Amp, action potential amplitude; AP half-width, action potential half-width.
*BS LV/VI aIC-BLA Saccharin 2x vs. CTA Retrieval, *p < 0.05, **p < 0.01, ***p < 0.001.
∼BS LV/VI aIC-BLA Extinction vs. Reinstatement, ∼p < 0.05, ∼∼p < 0.01, ∼∼∼p < 0.001.
#BS LV/VI aIC-BLA Saccharin 1x vs. Quinine 1x, Saccharin 5x and Saccharin 1x (4hr), #p < 0.05, ##p < 0.01.