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. 2022 Jan 21;29(3):469–486. doi: 10.3748/wjg.v29.i3.469

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©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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The schematic diagram of ferroptosis. PUFAs: Polyunsaturated fatty acids; PLOOHs: Phospholipid hydroperoxides; GSH: Glutathione; Nrf2: Nuclear factor erythroid2-related factor 2; GPx4: Glutathione peroxidase 4.