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. Author manuscript; available in PMC: 2023 Jan 19.
Published in final edited form as: J Bone Miner Res. 2016 Sep 26;32(2):385–396. doi: 10.1002/jbmr.2986

Fig. 6.

Fig. 6.

Pathological osteoclast function and bone remodeling in TRPML1−/− mice. For the in vivo experiments, proximal femoral bones and tibias were isolated from WT and TRPML1−/− mice and used for histological analysis and μCT. (A) Bone sections were stained for TRAP. The Oc.S/BS (%) was analyzed, and results are presented as fold change relative to WT. (Scale bar = 100 μm). Dashed line demarcates the E.P. (B) μCT images of proximal femur obtained from WT and TRPML1−/− mice. Each parameter, including BV, BV/TV, BMD, Tb.N, Tb.Th, Tb.Sp, and SMI were calculated and are presented. *p < 0.05, **p < 0.01. (Scale bar = 500 μm). Oc.S/BS = osteoclast surface; E.P = epiphyseal plate; T.O = TRAP+ osteoclasts; T.B = trabecular bone; BV = bone volume; BV/TV = bone volume per tissue volume; BMD = bone mineral density; Tb.N = trabecular number; Tb.Th = trabecular thickness; Tb.Sp = trabecular separation; SMI = structure model index.

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