Table 4.
Aberrant exosomal non-coding RNAs and their targets in the chemoresistance of colorectal cancer
|
Exosomal ncRNAs1
|
Donor cells
|
Recipient cells
|
Targets and pathways
|
Ref.
|
| miR-21↓ | THLG-293T/LG-293T cells | CRC cells | - | [156] |
| miR-208b↑ | CRC cells | T cells | PDCD4 | [145] |
| miR-92a-3p↑ | CAFs cells | CRC cells | FBXW7/MOAP1 | [20] |
| miR-46146↑ | CRC-R cells | CRC-S cells | PDCD10 | [146] |
| miR-1915-3p↓ | FHC cells | CRC cells | PFKFB3/USP2 | [147] |
| lncRNA H19↑ | CAFs cells | CRC cells | - | [141] |
| lncRNA CCAL↑ | CAFs cells | CRC cells | HuR/β-catenin | [142] |
| cricN4BP2L2 | CAFs cells | CRC cells | EIF4A3/PI3K/AKT/mTOR | [143] |
| ciRS-122↑ | CRC-R cells | CRC-S cells | miR-122/PKM2 | [148] |
| circ_0094343↓ | NCM460 cells | CRC cells | miR-766-5p/TRIM67 | [144] |
1
Aberrant exosomal ncRNAs are either up-regulated (↑) or down-regulated (↓) in CRC oxaliplatin resistance. CRC-R cells and CRC-S cells represent oxaliplatin-resistant and oxaliplatin-sensitive cells, respectively.
ncRNAs: Non-coding RNAs; CRC: Colorectal cancer; CAFs: Cancer-associated fibroblasts.