Table 2.
Studies reporting endoscopic ultrasound-radiofrequency ablation for pancreatic adenocarcinoma
|
Ref.
|
Study type
|
Patients/RFA session, n
|
Tumor location (n)
|
Cancer stage (n)
|
Mean size (range) in mm
|
Any decrease in tumor size, n (%)
|
Technical success, n (%)
|
Adverse events, n (%)
|
Mean follow-up in mo
|
Survival after RFA in mo
|
| Arcidiacono et al[16] | Prospective | 22/22 | Head (16), uncinate (2), body (4) | Locally advanced (22) | 35.7 (23-54) | 6 (37.5) | 16 (72.7) | 8 (36.4)1 | 3 | 5.6 (1-12) |
| Song et al[32] | Prospective | 6/8 | Head (4), body (2) | Locally advanced (4), metastasis (2) | 48 (30-90) | NR | 6 (100) | 2 (25)2 | 4.2 | NR |
| Scopelliti et al[17] | Prospective | 10/10 | Head (4), body (6) | Locally advanced (10) | 49.2 (25-75) | 10 (100) | 10 (100) | 4 (40)3 | 1 | NR |
| Crinò et al[18] | Retrospective | 7/7 | Head (2), body (3), uncinate (2) | Locally advanced (7) | 36 (22-67) | 7 (100) | 7 (100) | 3 (42.8)4 | 6.1 | NR |
| Paiella et al[19] | Retrospective | 30/30 | Head (23), body and tail (7) | Locally advanced (30) | 35 (20-60) | NR | 30 (100) | 1 (3.3)5 | 15 | 15 |
| Bang et al[20] | Prospective | 12/12 | Head and uncinate (8), body and tail (4) | Locally advanced (5), metastasis (7) | 29.6 (22.5-35.0) | NR | 12 (100) | 5 (41.6)6 | 1 | NR |
| Wang et al[33] | Retrospective | 11/26 | Head (4), neck (3), body (3), tail (1) | Locally advanced (7), metastasis (4) | 28 (17.2-38) | 2 (18.2) | 11 (100) | 2 (7.7)7 | 5.2 | 5.2 |
| Oh et al[34] | Prospective | 22/107 | Head (14), body (4), tail (3), metastasis (1) | Locally advanced (14), metastatic (8) | 38 (32.8-45.0) | NR | 22 (100) | 4 (3.7)8 | 21.2 | 24 |
| Pooled data | Prospective: 5. Retrospective: 3 | 120/222 | Head and uncinate (79). Body and tail (37), neck (3) | Locally advanced (100), metastasis (21) | 37.4 | Unable to pool due to data lacking | 114 (95) | 29 (13) | 7.1 | Unable to pool due to data lacking |
Transient abdominal pain (3 patients, mild), minor duodenal bleeding endoscopically treated (1 patient, moderate), transient amylase elevation (3 patients, mild), transient cystic fluid collection between pancreas and left hepatic lobe (1 patient, mild).
Transient abdominal pain (2 patients, mild).
Mild pancreatitis (4 patients, mild).
Transient abdominal pain (3 patients, mild).
Duodenal bleeding (1 patient, moderate).
Nausea and vomiting (4 patients, mild), transient abdominal pain (1 patient, mild).
Transient abdominal pain (2 patients, mild).
Transient abdominal pain (3 patients, mild), peritonitis (1 patient, moderate).
NR: Not reported; RFA: Radiofrequency ablation.