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. 2023 Jan 16;11(2):268–291. doi: 10.12998/wjcc.v11.i2.268

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©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

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Mechanism underlying hematopoietic stem and progenitor cells homing and engraftment. Numerous adhesion molecules and chemokines are involved in the regulation of hematopoietic stem and progenitor cells (HSPCs) homing and engraftment. The interaction between recipient bone marrow stromal cells and donor HSPCs contributes to HSPC homing and engraftment. In addition, donor HSPCs improve the metabolism of recipient bone marrow stromal cells via mitochondrial transfer, accelerating the recovery of damaged bone marrow stromal cells. Ca²⁺: Calcium; CXCR4: C-X-C chemokine receptor 4; ICAM-1: Intercellular adhesion molecule-1; LFA-1: Lymphocyte function-associated antigen-1; MMP-2: Matrix metalloproteinase 2; MMP-9: Matrix metalloproteinase 9; Opn: Osteopontin; SCF: Stem cell factor; SDF-1: Stromal derived factor-1; TPO: Thrombopoietin; VCAM-1: Vascular cell adhesion molecule-1; VLA-4: Very late antigen 4.