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. 2022 Dec 26;10(36):13264–13273. doi: 10.12998/wjcc.v10.i36.13264

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©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

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Representative case (case 1). A 67-yr-old female who underwent endoscopic resection for large superficial esophageal squamous cell carcinoma. A: Endoscopic view of the tumor after Lugol’s staining. The tumor spread to more than 3/4 of the circumference of the esophageal lumen; B: Endoscopic view of the ulcer bed immediately after endoscopic submucosal dissection. The width of the mucosal defect was ≥ 3/4 and less than the entire circumference. Then oral steroid was administered as a prophylactic treatment; C: Endoscopic view on the 30^th d. The mucosal defect was still undergoing re-epithelialization, and a 9.9 mm diameter gastroscope (Olympus GIF-Q260J) could pass. D: Endoscopic view on the 180^th d; Complete epithelialization is shown and a 9.9 mm diameter gastroscope (Olympus GIF-Q260J) could pass without dysphagia.